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Phase I and Phase II clinical trials have been finished and the results will be published separately. The refined structure of dicycloplatin has been deposited at the CCDC Cambridge Crystallographic Data Centre ; the reference code is CCDC The crystallographic data, the cell parameters and the refined R-indices of carboplatin and dicycloplatin are given in Table 1.
The structure of carboplatin Figure 1 appears to be identical to the published result . The molecular structure of carboplatin possesses a mirror plane which is located on the plane consisting of the Pt atom and the 1,1-cyclobutyl group.
The average bond angle in the cyclobutane ring is 90q resulting in strong strain within the ring. The coordinated atoms of the ligands and the Pt II center are located in the same plane, which is perpendicular to the cyclobutane ring.
In the crystal, a hydrogen bond is formed between a carboxylate oxygen atom and the NH3 group from a neighboring molecule.
With a distance between the proton donor and the acceptor of about 0. The crystal structure of dicycloplatin shows that it consists of molecules of carboplatin and cyclobutane-1,1-dicarboxylic Table 1 Crystal data and structure refinement for carboplatin and dicycloplatin 2 Materials and methods Carboplatin Dicycloplatin C12H20N2O8Pt Crystals of carboplatin were obtained from a saturated aqueous solution at room temperature.
A total of reflections were collected. The structures were solved and refined using Shelx . Graphical representations of the structures were produced using the program PyMol unless otherwise specified .
Figure 3 The structure of the cyclobutane-1,1-dicarboxylic acid moiety in dicycloplatin. Both carboplatin and the CBDC are neutral and the molecular ratio is The carboplatin moiety in the dicycloplatin structure is virtually identical to that in carboplatin Figure 2.
The structure of the cyclobutane-1,1-dicarboxylic acid moiety is shown in Figure 3. This is due to the formation of strong intermolecular hydrogen bonds.
Dicycloplatin is composed of carboplatin and CBDC, which are linked through strong hydrogen bonds and can therefore be regarded as a supramolecule.
Two types of hydrogen bonds were observed in the crystal structure. O hydrogen bonds with the carboxyl oxygen atoms of carboplatin, with the distances between the donor oxygen and acceptor oxygen atoms being 0.
O hydrogen bonds with the carboplatin molecule located between them. This hydrogen bonding scheme is repeated along the b axis leading to the formation of a one-dimensional chain polymer of carboplatin and CBDC.
Another type of hydrogen bond is formed between the NH3 groups of carboplatin and the oxygen atoms of CBDC. The distance between the nitrogen and oxygen atoms is around 0.
O hydrogen bonds giving rise to a two-dimensional planar polymer of the dicycloplatin supramolecule. The plane of the two-dimensional dicycloplatin supramolecule is parallel to the crystallographic ab plane.
In the electrospray mass spectrum ESI-MS of dicycloplatin in aqueous solution Figure 6 , an M-1 peak Figure 2 The structure of the carbop1atin moiety in dicycloplatin.
Figure 4 The one-dimensional hydrogen bonded polymer structure of dicycloplatin along the b axis.
YANG XuQing, et al. Figure 6 solution. The electrospray mass spectrum of dicycloplatin in the aqueous appeared at The strength of a hydrogen bond is between that of a covalent bond and van der Waals interactions.
The intramolecular and intermolecular hydrogen bonds in aqueous solution are in a constant process of formation and breakdown.
O intermolecular hydrogen bonds break and one-dimensional chains of dicycloplatin are formed; secondly, one of the strong hydrogen bonds in the chains of dicycloplatin supramolecules breaks, leading to an intermediate state of dicycloplatin Figure 7 ; thirdly, rearrangement of the relative orientations of the carboplatin and the CBDC molecule leads to the formation of intramolecular hydrogen bonds.
O hydrogen bonds, is then Figure 7 The intermediate structure of dicycloplatin in the aqueous solution. A hypothetical structural model of dicycloplatin in solution was made using the program O .
The carboplatin and CBDC molecules were kept rigid, based on their structures in the crystal, and the orientation of the carboxyl groups on CBDC was finely adjusted so that the distances between the oxygen atoms and the nitrogen atoms become optimal for hydrogen bonding.
The energy of the model was then minimized using the program XPLOR . O hydrogen bonds. The molecular weight of dicycloplatin is higher than that of carboplatin This hypothetical solution structure may explain the higher solubility and lipophilicity of dicycloplatin compared to carboplatin.
A schematic drawing of the dicycloplatin supramolecule in aqueous solution is shown in Figure 8 b. Precipitation was observed in the carboplatin solution after about one week; a black powder of platinum appeared subsequently.
However the solution of dicycloplatin, kept under the same conditions, remains clear to date. Figure 9 Comparison of the mass and NMR spectra of freshly synthesized dicycloplatin and that stored for over 10 years revealed only negligible differences data not shown.
It is known that carboplatin is unstable in aqueous solution because the 1,1-cyclobutane dicarboxylate group in carboplatin accepts protons from water and hydrolysis of carboplatin takes place Figure Figure 10 Hydrolysis of carboplatin.
Furthermore, the structure of dicycloplatin is designed so that the proton exchange between the carboplatin moiety and the CDBC moiety will result in the same product Figure This mechanism fits well to the experimental results indicating that the supramolecular model of DCP is reasonable.
The structural features of dicycloplatin resulted in a number of advantages over traditional platinum-based drugs, such as increased solubility and stability in aqueous solution.
The statistical results of the Phase II trial will be published separately. Weishan Cui and Mr. Jinli Yang. Nature, , — Rosenberg B, VanCamp L, Trosko JE, Mansour VH.
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Acta Crystallogr A, , — Brunger AT. Shop products that look good together. Collection 1 1 Collection 1 1. Previous page. Next page. Like or dislike for instant recommendations.
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